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REACH Publications

Publications resulting from REACH funding include:

Adam Quirk D, Johnson ME, Anderson DE, Smuck M, Sun R, Matthew R, Bailey J, Marras WS, Bell KM, Darwin J, Bowden AE. Biomechanical Phenotyping of Chronic Low Back Pain: Protocol for BACPAC. Pain Med. 2022 Oct 31:pnac163. doi: 10.1093/pm/pnac163. Epub ahead of print. PMID: 36315101.

Alter BJ, Aung MS, Strigo IA, Fields HL. Onset hyperalgesia and offset analgesia: Transient increases or decreases of noxious thermal stimulus intensity robustly modulate subsequent perceived pain intensity. PLoS One. 2020 Dec 8;15(12):e0231124. doi: 10.1371/journal.pone.0231124. eCollection 2020. PMID: 33290407.

Ballatori AM, Shahrestani S, Nyayapati P, Agarwal V, Krug R, Han M, Fields AJ, O'Neill C, Demir-Deviren S, Lotz JC, Bailey JF. Influence of patient-specific factors when comparing multifidus fat infiltration between chronic low back pain patients and asymptomatic controls. JOR Spine. 2022 Jul 14;5(4):e1217. doi: 10.1002/jsp2.1217. PMID: 36601370; PMCID: PMC9799081.

Batorsky A, Bowden AE, Darwin J, Fields AJ, Greco CM, Harris RE, Hue TF, Kakyomya J, Mehling W, O'Neill C, Patterson CG, Piva SR, Sollmann N, Toups V, Wasan AD, Wasserman R, Williams DA, Vo NV, Psioda MA, McCumber M. The BACPAC Research Program Data Harmonization: Rationale for Data Elements and Standards. Pain Med. 2023 Jan 31:pnad008. doi: 10.1093/pm/pnad008. Epub ahead of print. PMID: 36721327.


Bonnheim NB, Lazar AA, Kumar A, Akkaya Z, Zhou J, Guo X, O'Neill C, Link TM, Lotz JC, Krug R, Fields AJ. ISSLS Prize in Bioengineering Science 2023: Age- and sex-related differences in lumbar intervertebral disc degeneration between patients with chronic low back pain and asymptomatic controls. Eur Spine J. 2023 Feb 18. doi: 10.1007/s00586-023-07542-6. Epub ahead of print. PMID: 36805320.

Bonnheim NB, Wang L, Lazar AA, Chachad R, Zhou J, Guo X, O’Neill C, Castellanos J, Du J, Jang H, Krug R, Fields AJ. Deep-learning-based biomarker of spinal cartilage endplate health using ultra-short echo time magnetic resonance imaging. Quant Imaging Med Surg 2023;13(5):2807-2821.

Bonnheim NB, Wang L, Lazar AA, Zhou J, Chachad R, Sollmann N, Guo X, Iriondo C, O'Neill C, Lotz JC, Link TM, Krug R, Fields AJ. The contributions of cartilage endplate composition and vertebral bone marrow fat to intervertebral disc degeneration in patients with chronic low back pain. Eur Spine J. 2022 Jul;31(7):1866-1872. doi: 10.1007/s00586-022-07206-x. Epub 2022 Apr 20. PMCID: PMC9252939.

Chau A, Steib S, Whitaker E, Kohns D, Quinter A, Craig A, Chiodo A, Chandran S, Laidlaw A, Schott Z, Farlow N, Yarjanian J, Omwanghe A, Wasserman R, O'Neill C, Clauw D, Bowden A, Marras W, Carey T, Mehling W, Hunt A, Lotz J. Theoretical Schemas to Guide BACPAC Chronic Low Back Pain Clinical Research. Pain Med. 2022 Dec 23:pnac196. doi: 10.1093/pm/pnac196. Epub ahead of print. PMID: 36562563.

Dudli S, Ballatori A, Bay-Jensen AC, McCormick ZL, O'Neill CW, Demir-Deviren S, Krug R, Heggli I, Juengel A, Karppinen J, Brunner F, Farshad M, Distler O, Lotz JC, Fields AJ. Serum Biomarkers for Connective Tissue and Basement Membrane Remodeling are Associated with Vertebral Endplate Bone Marrow Lesions as Seen on MRI (Modic Changes). Int J Mol Sci. 2020 May 27;21(11):3791. doi: 10.3390/ijms21113791. PMID: 32471173; PMCID: PMC7312719.

Fields AJ, Ballatori A, Han M, Bailey JF, McCormick ZL, O'Neill CW, Demir-Deviren S, Krug R, Lotz JC. Measurement of vertebral endplate bone marrow lesion (Modic change) composition with water-fat MRI and relationship to patient-reported outcome measures. Eur Spine J. 2021 Sep;30(9):2549-2556. doi: 10.1007/s00586-021-06738-y. Epub 2021 Feb 6. PMID: 33547944; PMCID: PMC8697722.

Fields AJ, Dudli S, Schrepf A, Kim A, Pham B, Gallego E, Mendoza S, Meropol SB, Darwin J, Sowa G, Vo NV. Protocol for Biospecimen Collection and Analysis within the BACPAC Research Program. Pain Med. 2022 Dec 16:pnac197. doi: 10.1093/pm/pnac197. Epub ahead of print. PMID: 36525387.

Garcia Guerra S, Spadoni A, Mitchell J, Strigo IA. Pain-related opioidergic and dopaminergic neurotransmission: Dual meta-Analyses of PET radioligand studies. Brain Res. 2023 Apr 15;1805:148268. doi: 10.1016/j.brainres.2023.148268. Epub 2023 Feb 6. PMID: 36754138

Greco CM, Wasan AD, Schneider MJ, Mehling W, Williams DA, Darwin J, Harte SE. Biobehavioral Assessments in BACPAC: Recommendations, Rationale, and Methods. Pain Med. 2022 Nov 12:pnac175. doi: 10.1093/pm/pnac175. Epub ahead of print. PMID: 36370080.

Halvorson RT, Torres-Espin A, Callahan M, Tay B, O'Neill C, Berven S, Lotz JC, Bailey JF. Multi-domain biopsychosocial postoperative recovery trajectories associate with patient outcomes following lumbar fusion. Eur Spine J. 2023 Apr;32(4):1429-1436. doi: 10.1007/s00586-023-07572-0. Epub 2023 Mar 6. PMID: 36877367.

Huie JR, Vashisht R, Galivanche A, Hadjadj C, Morshed S, Butte AJ, Ferguson AR, O'Neill C. Toward a causal model of chronic back pain: Challenges and opportunities. Front Comput Neurosci. 2023 Jan 11;16:1017412. doi: 10.3389/fncom.2022.1017412. PMID: 36714527; PMCID: PMC9874096.

Keller AV, Torres-Espin A, Peterson TA, Booker J, O'Neill C, Lotz JC, Bailey JF, Ferguson AR, Matthew RP. Unsupervised Machine Learning on Motion Capture Data Uncovers Movement Strategies in Low Back Pain. Front Bioeng Biotechnol. 2022 Apr 14;10:868684. doi: 10.3389/fbioe.2022.868684. PMCID: PMC9047543.

Khattab K, Dziesinski LK, Crawford R, Ballatori A, Nyayapati P, Krug R, Fields A, O'Neill CW, Lotz JC, Bailey JF. Spatial distribution of fat infiltration within the paraspinal muscles: implications for chronic low back pain. Eur Spine J. 2022 Jul 1. doi: 10.1007/s00586-022-07296-7. Epub ahead of print. PMID: 35776179.

Mauck MC, Aylward AF, Barton CE, Birckhead B, Carey T, Dalton DM, Fields AJ, Fritz J, Hassett AL, Hoffmeyer A, Jones SB, McLean SA, Mehling WE, O'Neill CW, Schneider MJ, Williams DA, Zheng P, Wasan AD. Evidence-based interventions to treat chronic low back pain: treatment selection for a personalized medicine approach. Pain Rep. 2022 Sep 30;7(5):e1019. doi: 10.1097/PR9.0000000000001019. PMID: 36203645; PMCID: PMC9529058.

Mauck MC, Lotz J, Psioda MA, Carey TS, Clauw DJ, Majumdar S, Marras WS, Vo N, Aylward A, Hoffmeyer A, Zheng P, Ivanova A, McCumber M, Carson C, Anstrom KJ, Bowden AE, Dalton D, Derr L, Dufour J, Fields AJ, Fritz J, Hassett AL, Harte SE, Hue TF, Krug R, Loggia ML, Mageswaran P, McLean SA, Mitchell UH, O'Neill C, Pedoia V, Quirk DA, Rhon DI, Rieke V, Shah L, Sowa G, Spiegel B, Wasan AD, Wey HM, LaVange L. The Back Pain Consortium (BACPAC) Research Program: Structure, Research Priorities, and Methods. Pain Med. 2023 Jan 9:pnac202. doi: 10.1093/pm/pnac202. Epub ahead of print. PMID: 36622041.

Murphy JL, Palyo SA, Schmidt ZS, Hollrah LN, Banou E, Van Keuren CP, Strigo IA. The Resurrection of Interdisciplinary Pain Rehabilitation: Outcomes Across a Veterans Affairs Collaborative. Pain Med. 2021 Feb 23;22(2):430-443. doi: 10.1093/pm/pnaa417. PMID: 33496787

Nyayapati P, Booker J, Wu PI, Theologis A, Dziesinski L, O'Neill C, Zheng P, Lotz JC, Matthew RP, Bailey JF. Compensatory biomechanics and spinal loading during dynamic maneuvers in patients with chronic low back pain. Eur Spine J. 2022 Jul;31(7):1889-1896. doi: 10.1007/s00586-022-07253-4. Epub 2022 May 20. PMID: 35604457; PMCID: PMC9252943.

Sollmann N, Bonnheim NB, Joseph GB, Chachad R, Zhou J, Akkaya Z, Pirmoazen AM, Bailey JF, Guo X, Lazar AA, Link TM, Fields AJ, Krug R. Paraspinal Muscle in Chronic Low Back Pain: Comparison Between Standard Parameters and Chemical Shift Encoding-Based Water-Fat MRI. J Magn Reson Imaging. 2022 Mar 14:10.1002/jmri.28145. doi: 10.1002/jmri.28145. Epub ahead of print. PMCID: PMC9470775.

Sollmann N, Fields AJ, O'Neill C, Nardo L, Majumdar S, Chin CT, Tosun D, Han M, Vu AT, Ozhinsky E, Shah LM, Harris RE, Lobo R, Anderst W, Herzog R, Psioda MA, Standaert CJ, Price RT, Lotz JC, Link TM, Krug R. Magnetic resonance imaging of the lumbar spine-recommendations for acquisition and image evaluation from the BACPAC Spine Imaging Working Group. Pain Med. 2022 Sep 7:pnac130. doi: 10.1093/pm/pnac130. Epub ahead of print. PMID: 36069660.

Strigo IA, Keltner JR, Ellis RJ, Simmons AN. Association of painful human immunodeficiency virus distal sensory polyneuropathy with aberrant expectation of pain relief: functional magnetic resonance imaging evidence. Brain Commun. 2021 Oct 30;3(4):fcab260. doi: 10.1093/braincomms/fcab260. PMID: 34859214; PMCID: PMC8633742.

Strigo IA, Simmons AN, Giebler J, Schilling JM, Moeller‑Bertram T. Unsupervised learning for prognostic validity in patients with chronic pain in transdisciplinary pain care. Scientific Reports

Strigo IA, Spadoni AD, Simmons AN. Understanding Pain and Trauma Symptoms in Veterans From Resting-State Connectivity: Unsupervised Modeling. Front Pain Res (Lausanne). 2022 May 10;3:871961. doi: 10.3389/fpain.2022.871961. PMCID: PMC9127988.

Toor T, Murphy E, Simmons AN, Palyo S, Librodo SC, Strigo IA. Craving of prescription opioids among veterans with chronic pain. Pain. 2022 Oct 1;163(10):2021-2030. doi: 10.1097/j.pain.0000000000002598. Epub 2022 Jan 28. PMCID: PMC9329486.

Torres-Espin A, Keller A, Johnson GTA, Fields AJ, Krug R, Ferguson AR, Hargens AR, O'Neill CW, Lotz JC, Bailey JF. Using hierarchical unsupervised learning to integrate and reduce multi-level and multi-paraspinal muscle MRI data in relation to low back pain. Eur Spine J. 2022 Aug;31(8):2046-2056. doi: 10.1007/s00586-022-07169-z. Epub 2022 Mar 25. PMID: 35333958; PMCID: PMC9338899.

Wang L, Han M, Wong J, Zheng P, Lazar AA, Krug R, Fields AJ. Evaluation of human cartilage endplate composition using MRI: Spatial variation, association with adjacent disc degeneration, and in vivo repeatability. J Orthop Res. 2021 Jul;39(7):1470-1478. doi: 10.1002/jor.24787. Epub 2020 Jul 7. PMID: 32592504; PMCID: PMC7765737.

​Wilson L, Denham A, Ionova Y, O'Neill C, Greco CM, Hassett AL, Hanmer J, Shaikh S, M W, Bervin S, Williams D, Ma Y, Lotz J, Zheng P. Preferences for Risks and Benefits of Treatment Outcomes for Chronic Low Back Pain: Choice-Based Conjoint Measure Development and Discrete Choice Experiment. PM R. 2023 Dec 1. doi: 10.1002/pmrj.13112. Epub ahead of print. PMID: 38040670.

Wilson L, Zheng P, Ionova Y, Denham A, Yoo C, Ma Y, Greco CM, Hanmer J, Williams DA, Hassett AL, Scheffler AW, Valone F, Mehling W, Berven S, Lotz J, O'Neill C. CAPER: Patient Preferences to Inform Non-Surgical Treatment of Chronic Low Back Pain (cLBP): A Discrete Choice Experiment. Pain Med. 2023 Mar 28:pnad038. doi: 10.1093/pm/pnad038. Epub ahead of print. PMID: 36975607.

Zhou J, Damasceno PF, Chachad R, Cheung JR, Ballatori A, Lotz JC, Lazar AA, Link TM, Fields AJ, Krug R. Automatic Vertebral Body Segmentation Based on Deep Learning of Dixon Images for Bone Marrow Fat Fraction Quantification. Front Endocrinol (Lausanne). 2020 Sep 2;11:612. doi: 10.3389/fendo.2020.00612. PMID: 32982989; PMCID: PMC7492292.

REACH faculty have broad expertise in their specific areas of research focus. Below we have highlighted some of their published work, as well as articles that may be of interested to the lower back pain community at large. 

Bailey JF, Fields AJ, Ballatori A, et al. The Relationship Between Endplate Pathology and Patient-reported Symptoms for Chronic Low Back Pain Depends on Lumbar Paraspinal Muscle Quality. Spine (Phila Pa 1976). 2019;44(14):1010‐1017. doi:10.1097/BRS.0000000000003035


Chan AK, Bisson EF, Bydon M, et al. A comparison of minimally invasive transforaminal lumbar interbody fusion and decompression alone for degenerative lumbar spondylolisthesis. Neurosurg Focus. 2019;46(5):E13. doi:10.3171/2019.2.FOCUS18722

Chan AK, Bisson EF, Bydon M, et al. Laminectomy alone versus fusion for grade 1 lumbar spondylolisthesis in 426 patients from the prospective Quality Outcomes Database. J Neurosurg Spine. 2018;30(2):234–241. doi:10.3171/2018.8.SPINE17913

Ghogawala Z, Shaffrey CI, Asher AL, Heary RF, Logvinenko T, Malhotra NR, Dante SJ, Hurlbert RJ, Douglas AF, Magge SN, Mummaneni PV, Cheng JS, Smith JS, Kaiser MG, Abbed KM, Sciubba DM, Resnick DK. The efficacy of lumbar discectomy and single-level fusion for spondylolisthesis: results from the NeuroPoint-SD registry: clinical article. J Neurosurg Spine. 2013 Nov;19(5):555-63. doi: 10.3171/2013.7.SPINE1362. Epub 2013 Sep 6.

Lotz JC, Fields AJ, Liebenberg EC. The role of the vertebral end plate in low back pain. Global Spine J. 2013;3(3):153‐164. doi:10.1055/s-0033-1347298

Krug R, Joseph GB, Han M, Fields A, Cheung J, Mundada M, Bailey J, Rochette A, Ballatori A, McCulloch CE, McCormick Z, O'Neill C, Link TM, Lotz J. Associations between vertebral body fat fraction and intervertebral disc biochemical composition as assessed by quantitative MRI. J Magn Reson Imaging. 2019.

Mummaneni PV, Whitmore RG, Curran JN, Ziewacz JE, Wadhwa R, Shaffrey CI, Asher AL, Heary RF, Cheng JS, Hurlbert RJ, Douglas AF, Smith JS, Malhotra NR, Dante SJ, Magge SN, Kaiser MG, Abbed KM, Resnick DK, Ghogawala Z. Cost-effectiveness of lumbar discectomy and single-level fusion for spondylolisthesis: experience with the NeuroPoint-SD registry. Neurosurg Focus. 2014 Jun;36(6):E3. doi: 10.3171/2014.3.FOCUS1450.


Than KD, Curran JN, Resnick DK, Shaffrey CI, Ghogawala Z, Mummaneni PV. How to predict return to work after lumbar discectomy: answers from the NeuroPoint-SD registry. J Neurosurg Spine. 2016 Aug;25(2):181-6. doi: 10.3171/2015.10.SPINE15455. Epub 2016 Mar 18. PMID: 26989977 Clinical Trial

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